Comfort Zones

I'm currently working on them for LOST IN SUBURBIA, which is women's fiction rather than romance, and even though the book is finished and under contract, I still feel like I'm out of my element. It's written in the first person point of view, which I don't normally do, and though there's a romance it's definitely not a traditional one. I really stepped out of my comfort zone with this one. Doing the edits has me thinking today. For the writers, what do you do when a story outside your comfort zone nags at you? Do you write it the way it comes to you? Do you try to shape it to fit what you normally write? Ignore it altogether?